The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

A compound from soil bacteria, corramycin, hits the same enzyme as fluoroquinolones, DNA gyrase, but binds differently, and worked against TB strains already resistant to them. Lab work only: it isn't yet cheap to make or tested in the body, and an earlier attempt stalled on cost.

Sources and attribution SOURCEThe Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosishttps://doi.org/10.1002/advs.76832